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Lupus Sci Med (2020) 7(1):e000429v

doi: 10.1038/s41392-020-00450-x 36 TaoLMuXChenHJinDZhangRZhaoYet al

Autophagy stabilizes Foxp3 transcription factor expression in Tregs, promotes synthesis of inhibitory cytokines like IL-10 and TGF-, and enhances their immunosuppressive effects on CD8 + T cells

Moreover, a polynucleotides or polypeptides, or agonists or antagonists of the present invention could also be used to modulate hemostatic (the stopping of bleeding) or thrombolytic activity (clot formation)

Although several targets, including peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) [100], methlentetrahydrofolate dehydrogenase 1 (MTHFD1) and mutated Nucleophosmin-1 (NPM1) [101, 102] have been identified, proteome-wide profiling of arsenic-binding proteins offers critical insights into ATOs mechanisms of action from a system perspective